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Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP Study

Sanders, TAB; Lewis, F; Slaughter, S; Griffin, BA; Griffin, M; Davies, I; ... Miller, GJ; + view all (2006) Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP Study. AM J CLIN NUTR , 84 (3) 513 - 522.

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Abstract

Background: Elevated fibrinogen, activated factor XII (FXIIa), and factor VII coagulant activity (FVIIc) are associated with higher risk of fatal ischemic heart disease. This study tested the hypothesis that lowering the dietary ratio of n-6 to n-3 polyunsaturated fatty acids (n-6:n-3) would modify these risk factors in older men and women.Objective: The objective of the study was to measure fasting hemostatic risk factors and postprandial changes in activated FVII (FVIIa) concentrations after a 6-mo alteration in dietary n-6: n-3.Design: In a randomized, parallel design in 258 subjects aged 45-70 y, we compared 4 diets providing 6% of energy as polyunsaturated fatty acids at an n-6:n-3 between 5:1 and 3:1 with a control diet that had an n-6:n-3 of 10:1. The diets were enriched in a-linolenic acid, eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid, or both.Results: Fasting and 3-h plasma triacylglycerol concentrations were 11.1 % and 7.2% lower with the diet that had an n-6: n-3 of approximate to 3:1 and that was enriched with EPA and DHA than with the other diets. Fasting fibrinogen, FXIIa, FVIIc, FVIIa, and FVII antigen and postprandial FVIIa were not influenced by the diets. Avoiding foods high in fat the day before measurement decreased FVIIc and FVIIa by 8% and 19.2%, respectively. A test meal containing 50 g fat resulted in a mean 47% (95% CI: 42%, 52%) increase in FVIIa 6 h later, but the response did not differ by n-6: n-3.Conclusion: Decreasing the n-6:n-3 to approximate to 3:1 by increasing the intake of EPA and DHA lowers fasting and postprandial plasma triacylglycerol concentrations in older persons but does not influence hemostatic risk factors.

Type:Article
Title:Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP Study
Keywords:factor VII, factor XII, n-3 fatty acids, ratio of n-6 to n-3 fatty acids, triacylglycerol, nonesterified fatty acids, fibrinogen, CORONARY-HEART-DISEASE, HEALTHY-MEN, FIBRINOLYTIC-ACTIVITY, POSTPRANDIAL LIPEMIA, PLASMA-LIPOPROTEINS, COAGULANT ACTIVITY, HEMOSTATIC FACTORS, RISK, ACTIVATION, ASSOCIATIONS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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