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Leukocyte telomere length is associated with measures of subclinical atherosclerosis

Panayiotou, AG; Nicolaides, AN; Griffin, M; Tyllis, T; Georgiou, N; Bond, D; ... Humphries, SE; + view all (2010) Leukocyte telomere length is associated with measures of subclinical atherosclerosis. ATHEROSCLEROSIS , 211 (1) 176 - 181. 10.1016/j.atherosclerosis.2010.01.037.

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Abstract

Aims: Our aim was to test the association of mean leukocyte telomere length (LTL) with ultrasonic measures of subclinical atherosclerosis such as intima-media thickness in the common carotid (IMTcc) and sum of plaque areas (SPA) and with serological markers.Methods and results: Carotid and femoral bifurcations were scanned in 762 general population volunteers (46% men) over 40. Four features were considered: (a) IMTcc, (b) sum plaque areas of carotid plaques (SPAcar), (c) sum plaque area of common femoral plaques (SPAfem) and (d) sum plaque area (SPA - sum of the plaque areas of the largest plaques present in each of both carotid and femoral bifurcations). Mean LTL was determined with a quantitative real-time PCR-based method. IMTcc was strongly associated with mean LTL both before and after correction for traditional risk factors (B = -0.002; 95% CI = -0.004 to -0.00; p = 0.014). In sex-specific analysis, the association was stronger in men (p for sex interaction < 0.001). SPAfem was associated with LTL in women before and after correction (B = -0.195; 95% CI = -0.38 to -0.01; p = 0.037) (p for sex interaction < 0.001). LTL was also associated with age and sex-adjusted levels of hsCRP (p = 0.012), sCD40L (p = 0.042), homocysteine (p = 0.006), creatinine (p = 0.02), ApoA1 (p = 0.01), Lp(a) (p = 0.04) and HOMA-IR (p = 0.008).Conclusions: Our results support the telomere hypothesis and highlight potential differences in the biological mechanisms leading to intima-media thickening and/or plaque formation between vascular beds. They may provide insights into a novel treatment of antisenescence to prevent atherosclerosis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Type:Article
Title:Leukocyte telomere length is associated with measures of subclinical atherosclerosis
DOI:10.1016/j.atherosclerosis.2010.01.037
Keywords:Aging, Atherosclerosis, Telomeres, IMT, Plaque area, CORONARY-ARTERY-DISEASE, INTIMA-MEDIA THICKNESS, CAROTID PLAQUE AREA, CARDIOVASCULAR-DISEASE, ENDOTHELIAL DYSFUNCTION, MYOCARDIAL-INFARCTION, INSULIN-RESISTANCE, HEART-DISEASE, RISK, MEN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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