Lin, CQ; Parrinello, S; Campisi, J; Desprez, PY; (1999) Regulation of mammary epithelial cell phenotypes by the helix-loop-helix protein, Id-1. ENDOCRINE-RELATED CANCER , 6 (1) 49 - 50.
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Mammary epithelial cells undergo cycles of proliferation, invasion, differentiation and apoptotic cell-death throughout adult life. The molecular mechanisms that regulate these complex and co-ordinated developmental programs are poorly understood. We have identified Id-1 protein, a negative regulator of basic helix-loop-helix transcription factors, as a critical regulator of these normal mammary epithelial cell phenotypes. We also found that Id-1 is an important regulator of the aggressive and invasive phenotype, as well as mediator of the effects of sex steroid hormones, in human breast cancer cells.
|Title:||Regulation of mammary epithelial cell phenotypes by the helix-loop-helix protein, Id-1|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > MRC/UCL Lab for Molecular Cell Biology|
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