Lin, CQ and Parrinello, S and Campisi, J and Desprez, PY (1999) Regulation of mammary epithelial cell phenotypes by the helix-loop-helix protein, Id-1. ENDOCRINE-RELATED CANCER , 6 (1) 49 - 50.
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Abstract
Mammary epithelial cells undergo cycles of proliferation, invasion, differentiation and apoptotic cell-death throughout adult life. The molecular mechanisms that regulate these complex and co-ordinated developmental programs are poorly understood. We have identified Id-1 protein, a negative regulator of basic helix-loop-helix transcription factors, as a critical regulator of these normal mammary epithelial cell phenotypes. We also found that Id-1 is an important regulator of the aggressive and invasive phenotype, as well as mediator of the effects of sex steroid hormones, in human breast cancer cells.
| Type: | Article |
|---|---|
| Title: | Regulation of mammary epithelial cell phenotypes by the helix-loop-helix protein, Id-1 |
| Location: | CAMBRIDGE, ENGLAND |
| Keywords: | APOPTOSIS, SUPPRESSION |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Laboratory for Molecular Cell Biology |
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