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Organ-specific collagen expression: Implications for renal disease

Alexakis, C; Maxwell, P; Bou-Gharios, G; (2006) Organ-specific collagen expression: Implications for renal disease. NEPHRON EXP NEPHROL , 102 (3-4) E71 - E75. 10.1159/000089684.

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Abstract

Chronic kidney disease is characterized by progressive accumulation of extracellular matrix and scarring, leading to the loss of kidney function. Excess deposition of the collagen family of proteins is the hallmark of kidney fibrosis. In this review, we survey the collagens that are associated with renal disease and we highlight the use of a transgenic approach to identify cis-acting sequences in the collagen type I promoter which are capable of directing collagen type I expression specifically in the kidney. Ultimately it may be possible to use this approach to halt the accumulation of collagen selectively in this organ. Copyright (c) 2006 S. Karger AG, Basel.

Type:Article
Title:Organ-specific collagen expression: Implications for renal disease
DOI:10.1159/000089684
Keywords:gene regulation, renal fibrosis, collagen promoter/enhancer, tissue-specific expression, FAR-UPSTREAM ENHANCER, BASEMENT-MEMBRANE COMPONENTS, TRANSGENIC MICE, GROWTH-FACTOR, IV COLLAGEN, XV COLLAGEN, COL1A2 GENE, TISSUE, KIDNEY, FIBROSIS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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