Maxwell, PH; (2005) A common pathway for genetic events leading to pheochromocytoma. CANCER CELL , 8 (2) 91 - 93. 10.1016/j.ccr.2005.07.012.
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Mutations in VHL, RET, NF1, SDHB, SDHC, and SDHD can give rise to pheochromocytoma/paraganglioma. These different genetic lesions may all act by decreasing the activity of a 2-oxoglutarate-dependent oxygenase, SM-20/EgIN3/PHD3, resulting in reduced apoptosis of neural crest cells during development.
|Title:||A common pathway for genetic events leading to pheochromocytoma|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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