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Insights into the role of the von Hippel-Lindau gene product - A key player in hypoxic regulation

Maxwell, PH; Pugh, CW; Ratcliffe, PJ; (2001) Insights into the role of the von Hippel-Lindau gene product - A key player in hypoxic regulation. EXP NEPHROL , 9 (4) 235 - 240.

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Abstract

Many adaptive responses to hypoxia involve changes in gene transcription mediated by the hypoxia-inducible factor 1 complex. Central to this is oxygen-dependent proteolysis of the alpha subunit, which has recently been shown to require the von Hippel-Lindau tumour-suppressor protein. This observation provides one mechanism by which inherited defects in the von Hippel-Lindau gene could cause features of the clinical syndrome, and offers insight into the events leading to sporadic clear cell renal cancer. Furthermore, it clearly implicates the von Hippel-Lindau tumour-suppressor protein in the biochemistry of oxygen sensing. Copyright (C) 2001 S. Karger AG, Basel.

Type:Article
Title:Insights into the role of the von Hippel-Lindau gene product - A key player in hypoxic regulation
Keywords:hypoxia, hypoxia-inducible factor 1, von Hippel-Lindau, oxygen, TUMOR-SUPPRESSOR PROTEIN, DEPENDENT PROTEOLYSIS, INDUCIBLE FACTORS, ANGIOGENESIS, BINDING, GROWTH, HIF-1-ALPHA, EXPRESSION, DISEASE, COMPLEX
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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