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Hypoxia and oxidative stress in breast cancer - Hypoxia signalling pathways

Pugh, CW; Gleadle, J; Maxwell, PH; (2001) Hypoxia and oxidative stress in breast cancer - Hypoxia signalling pathways. BREAST CANCER RES , 3 (5) 313 - 317.

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Abstract

Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately linked to the proliferative stimulus itself. HIF affects patterns of gene expression and tumour growth, although precise effects vary between tumour types. Modulation of HIF activity, if correctly applied, may be therapeutically beneficial in tumour therapy.

Type:Article
Title:Hypoxia and oxidative stress in breast cancer - Hypoxia signalling pathways
Keywords:angiogenesis, hypoxia-inducible factor, oxygen, tumour, von Hippel-Lindau, INDUCIBLE FACTOR 1-ALPHA, ENDOTHELIAL GROWTH-FACTOR, TUMOR-SUPPRESSOR PROTEIN, GENE-EXPRESSION, FACTOR-I, HIF-1-ALPHA, CELLS, ANGIOGENESIS, HIF-1, OVEREXPRESSION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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