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Hypoxia-inducible factor as a physiological regulator

Maxwell, PH; (2005) Hypoxia-inducible factor as a physiological regulator. EXP PHYSIOL , 90 (6) 791 - 797. 10.1113/expphysiol.2005.030924.

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Abstract

Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator that coordinates changes in gene transcription. HIF operates in all mammalian cell types and is ancient in evolutionary terms, being conserved in C. elegans and D. melanogaster. This review summarizes recent insights into the molecular events that link reduced oxygenation to HIF activation and emerging insights into the extensive role of HIF in a broad range of physiological processes.

Type:Article
Title:Hypoxia-inducible factor as a physiological regulator
DOI:10.1113/expphysiol.2005.030924
Keywords:MICE PARTIALLY DEFICIENT, PROLYL HYDROXYLASE, FACTOR 1-ALPHA, HIF, HIF-1-ALPHA, FACTOR-1-ALPHA, HOMEOSTASIS, INHIBITION, GROWTH, ERYTHROPOIETIN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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