Shearman, AM and Cooper, JA and Kotwinski, PJ and Miller, GJ and Humphries, SE and Ardlie, KG and Jordan, B and Irenze, K and Lunetta, KL and Schuit, SCE and Uitterlinden, AG and Pols, HAP and Demissie, S and Cupples, LA and Mendelsohn, ME and Levy, D and Housman, DE (2006) Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. CIRC RES , 98 (5) 590 - 592. 10.1161/01.RES.0000210578.62102.a6.
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Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor alpha(ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c. 454-397T > C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio = 1.44; P < 0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63).
|Title:||Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts|
|Keywords:||genetics, myocardial infarction, estrogen receptor, risk factors, HORMONE REPLACEMENT THERAPY, CORONARY-ARTERY-DISEASE, POLYMORPHISMS, GENOTYPE, WOMEN|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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