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A functional polymorphic variant in the interleukin-6 gene prompter associated with low bone resorption in postmenopausal women

Ferrari, SL; Garnero, P; Emond, S; Montgomery, H; Humphries, SE; Greenspan, SL; (2001) A functional polymorphic variant in the interleukin-6 gene prompter associated with low bone resorption in postmenopausal women. ARTHRITIS RHEUM , 44 (1) 196 - 201.

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Abstract

Objective, To examine functional interleukin-6 (IL-6) -174 G-->C allelic variants in relation to bone turnover and bone mineral density (BMD) in postmenopausal women.Methods. Four hundred thirty-four healthy women living in the community (mean +/- SD age 71.7 +/- 5.7 years) were genotyped for the IL-6 -174 G-->C polymorphism. Serum levels of C-telopeptide of type I collagen (CTx), a marker of bone resorption, and osteocalcin (OC), a marker of bone formation, were determined, BMD at the hip and forearm was measured by dual-energy x-ray absorptiometry.Results. CTx levels differed significantly (P = 0.006) among IL-6 genotypes (mean +/- SEM 0.275 +/- 0.02 ng/ml, 0.325 +/- 0.01 ng/ml, and 0.356 +/- 0.02 ng/ml in women with the CC genotype [n = 68], the GC genotype [n = 204], and the GG genotype [n = 162], respectively), Compared with the GG group, age-adjusted odds ratios for high bone resorption were 0.65 (95% confidence interval [95% CI] 0.41-1.0, P = 0.06) and 0.37 (95% CI 0.18-0.73, P = 0.0047) in GC and CC subjects, respectively. In contrast, OC levels did not differ by genotype. BMD at the hip and forearm was 1.5-5% higher in CC subjects compared with GG subjects (P not significant). When the cohort was divided according to the median age (70.5 years), BMD was significantly decreased in older compared with younger postmenopausal women with the GC and GC genotypes (-9.6% on average; P < 0.01), but not in those with the CC genotype (-5.1% on average; P not significant).Conclusion. Compared with the GC and GG IL-6 -174 G-->C genotypes, the CC genotype is associated with lower bone resorption and lesser decrease in bone mass in older postmenopausal women. These results suggest that IL-6 - 174 G-->C alleles may be significant determinants of the risk for osteoporosis in elderly subjects.

Type:Article
Title:A functional polymorphic variant in the interleukin-6 gene prompter associated with low bone resorption in postmenopausal women
Keywords:ESTROGEN-RECEPTOR GENE, VITAMIN-D, RHEUMATOID-ARTHRITIS, BIOCHEMICAL MARKERS, MINERAL DENSITY, ALENDRONATE THERAPY, TURNOVER PREDICT, OSTEOPOROSIS, MECHANISMS, COLLAGEN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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