Margaret, D and Sanders, TAB and Davies, IG and Morgan, LM and Millward, DJ and Lewis, F and Slaughter, S and Cooper, JA and Miller, GJ and Griffin, BA (2006) Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. AM J CLIN NUTR , 84 (6) 1290 - 1298.
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Background: Insulin resistance is associated with elevated plasma triacylglycerol, low HDL concentrations, elevated postprandial lipemia, and a predominance of small, dense LDLs (sdLDLs). It has been hypothesized that the dietary ratio of n-6 to n-3 (n-6:n-3) polyunsaturated fatty acids (PUFAs) may have favorable effects on these risk factors by increasing insulin sensitivity.Objective: The objective was to measure changes in insulin sensitivity, lipoprotein size, and postprandial lipemia after a 6-mo alteration in n-6:n-3.Design: In a randomized, parallel design in 258 subjects aged 45-70 y, we compared 4 diets providing 6% of energy as PUFAs with an n-6:n-3 between 5:1 and 3:1 with a control diet that had an n-6: n-3 of 10:1. The diets were enriched in a-linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), or both. Insulin sensitivity was assessed with the homeostatic model assessment of insulin resistance and the revised quantitative insulin sensitivity test.Results: Dietary intervention did not influence insulin sensitivity or postprandial lipase activities. Fasting and postprandial triacylglycerol concentrations were lower, and the proportion of sdLDLs decreased (by 12.7%; 95% CI:-22.9%, 2.4%), with an n-6:n-3 of approximate to 3: 1, which was achieved by the addition of long-chain n-3 PUFAs (EPA and DHA).Conclusions: Decreasing the n-6:n-3 does not influence insulin sensitivity or lipase activities in older subjects. The reduction in plasma triacylglycerol after an increased intake of n-3 long-chain PUFAs results in favorable changes in LDL size.
|Title:||Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study|
|Keywords:||blood lipids, n-3 fatty acids, n-6 fatty acids, insulin sensitivity, lipoprotein lipase, LDL, HDL, long-chain polyunsaturated fatty acids, CORONARY-HEART-DISEASE, HOMEOSTASIS MODEL ASSESSMENT, ALPHA-LINOLENIC ACID, FISH-OIL, DOCOSAHEXAENOIC ACID, CARDIOVASCULAR-DISEASE, BLOOD-PRESSURE, HIGH-DENSITY, HEALTHY-MEN, LDL|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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