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Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution

Passos, D; Hebden, JC; Pinto, PN; Guerra, R; (2005) Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution. J BIOMED OPT , 10 (6) , Article 064036. 10.1117/1.2139971.

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Abstract

We demonstrate experimentally the possibility of reproducing the phase function, absorption, and scattering coefficients of a real biological tissue ( adult brain white matter and liver ) using a suspension of polystyrene microspheres with a fractal size distribution. The design of a light scattering goniometer with a cylindrical cell in air is discussed, and phase function measurements using the device are described. The scattering coefficient is measured using transmission spectrophotometry and the absorption and reduced scattering coefficients are measured using a time- resolved method. A good match between real tissue and phantom parameters is demonstrated. (C) 2005 Society of Photo- Optical Instrumentation Engineers.

Type:Article
Title:Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution
DOI:10.1117/1.2139971
Keywords:phantoms, light scattering goniometry, phase function, time-of-flight measurements, polystyrene, LIGHT-SCATTERING, REPRODUCIBLE PHANTOM, MULTIPLE-SCATTERING, BIOLOGICAL TISSUES, ABSORBING MEDIUM, VISIBLE REGION, WATER, ABSORPTION, SPECTROSCOPY, TOMOGRAPHY
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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