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The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites

Rechner, AR; Kuhnle, G; Hu, HL; Roedig-Penman, A; van den Braak, MH; Moore, KP; Rice-Evans, CA; (2002) The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. FREE RADICAL RES , 36 (11) 1229 - 1241. 10.1080/1071576021000016472.

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Abstract

Berry extracts rich in anthocyanins have been linked to protective effects including the modulation of age-related neurological dysfunction and the improvement of the resistance of red blood cells against oxidative stress in vitro. In this study the bioavailability, metabolism and elimination of polyphenols from blackcurrant juice, rich in anthocyanins, flavonols, and hydroxycinnamates, were investigated. The four major native anthocyanidin glycosides of blackcurrant juice, delphinidin-3-glucoside, delphinidin-3-rutinoside, cyanidin-3-glucoside and cyanidin-3-rutinoside, were detected and identified in low amounts by HPLC and LC-MS in plasma and urine post-ingestion. Elimination of the anthocyanins was fast (maximum excretion after I h) and plasma levels (0-128.6nmol/l) and total urinary excretion (0.07-1.35 mg; 0.007-0.133% of the dose ingested) were low. Most significantly, of the hydroxycinnamates, conjugated and free ferulic, isoferulic, p-coumaric, sinapic and vanillic acids were identified in plasma and urine, using GC-MS techniques. Quercetin and kaempferol (as glucuronides) and the proposed colonic metabolite of quercetin, 3-hydroxyphenylacetic acid, were detectable in a minority of subjects. Increased daily urinary hippuric, 4-hydroxy-hippuric and 3-hydroxyhippuric acid levels were also observed post-ingestion in all volunteers.

Type: Article
Title: The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites
DOI: 10.1080/1071576021000016472
Keywords: blackcurrant, anthocyanins, hydroxycinnamates, flavonols, absorption, metabolism, LOW-DENSITY-LIPOPROTEIN, HUMAN INTESTINAL BACTERIA, ANTIOXIDANT ACTIVITY, URINARY METABOLITES, ACID-DERIVATIVES, RED WINE, HUMANS, ANTHOCYANINS, FLAVONOIDS, QUERCETIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/117876
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