Jalan, R;
Pollok, A;
Shah, SHA;
Madhavan, KK;
Simpson, KJ;
(2002)
Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure.
J HEPATOL
, 37
(4)
536 - 538.
Abstract
We describe a patient with paracetamol induced acute liver failure (ALF) who fulfilled criteria for poor prognosis and was waiting for a liver to become available for transplantation. Because of severe uncontrolled intracranial hypertension she underwent a hepatectomy that resulted in stabilization of her systemic and cerebral hemodynamics. She remained anhepatic for 14 h and was successfully bridged to liver transplantation. The removal of the liver was associated with a sharp and sustained reduction in the circulating pro-inflammatory cytokine concentration suggesting that liver derived pro-inflammatory cytokines may be important in the pathogenesis of intracranial hypertension in patients with ALF. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure |
| Keywords: | FULMINANT HEPATIC-FAILURE, MODERATE HYPOTHERMIA, TOTAL HEPATECTOMY, CEREBRAL EDEMA |
| UCL classification: | UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | http://discovery.ucl.ac.uk/id/eprint/117875 |
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