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Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure

Jalan, R; Pollok, A; Shah, SHA; Madhavan, KK; Simpson, KJ; (2002) Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure. J HEPATOL , 37 (4) 536 - 538.

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Abstract

We describe a patient with paracetamol induced acute liver failure (ALF) who fulfilled criteria for poor prognosis and was waiting for a liver to become available for transplantation. Because of severe uncontrolled intracranial hypertension she underwent a hepatectomy that resulted in stabilization of her systemic and cerebral hemodynamics. She remained anhepatic for 14 h and was successfully bridged to liver transplantation. The removal of the liver was associated with a sharp and sustained reduction in the circulating pro-inflammatory cytokine concentration suggesting that liver derived pro-inflammatory cytokines may be important in the pathogenesis of intracranial hypertension in patients with ALF. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.

Type: Article
Title: Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure
Keywords: FULMINANT HEPATIC-FAILURE, MODERATE HYPOTHERMIA, TOTAL HEPATECTOMY, CEREBRAL EDEMA
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/117875
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