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The metabolic fate of dietary polyphenols in humans

Rechner, AR; Kuhnle, G; Bremner, P; Hubbard, GP; Moore, KP; Rice-Evans, CA; (2002) The metabolic fate of dietary polyphenols in humans. FREE RADICAL BIO MED , 33 (2) 220 - 235.

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Abstract

Dietary polyphenols are widely considered to contribute to health benefits in humans. However, little is yet known concerning their bioactive forms in vivo and the mechanisms by which they may contribute toward disease prevention. Although many studies are focusing on the bioavailability of polyphenols through studying their uptake and the excretion of their conjugated forms, few are emphasizing the occurrence of metabolites in vivo formed via degradation by the enzymes of colonic bacteria and subsequent absorption. The purpose of this research was to investigate the relationship between biomarkers of the colonic biotransformation of ingested dietary polyphenols and the absorbed conjugated polyphenols. The results show that the majority of the in vivo forms derive from cleavage products of the action of colonic bacterial enzymes and subsequent metabolism in the liver. Those include the glucuronides of 3-hydroxyphenylacetic, homovanillic, vanillic and isoferulic acid as well as 3-(3-methoxy-4-hydroxyphenyl)-propionic, 3-(3-hydroxyphenyl)-propionic acid, and 3-hydroxyhippuric acid. In contrast, intact conjugated polyphenols themselves, such as the glucuronides of quercetin, naringenin and ferulic, p-coumaric, and sinapic acid were detected at much lower levels. The results suggest that consideration should be given to the cleavage products as having a putative role as physiologically relevant bioactive components in vivo. (C) 2002 Elsevier Science Inc.

Type: Article
Title: The metabolic fate of dietary polyphenols in humans
Keywords: absorption, metabolism, excretion, naringenin, quercetin, dihydroferulic acid, 3-(3-hydroxyphenyl)-propionic acid, hydroxycinnamates, 3-hydroxyhippuric acid, hippuric acid, bioavailability, GC-MS, free radicals, CAFFEIC ACID-DERIVATIVES, SMALL-INTESTINE, HUMAN URINE, IN-VIVO, HYDROXYCINNAMIC ACIDS, GRAPEFRUIT JUICE, O-METHYLATION, HUMAN PLASMA, TEA, BIOAVAILABILITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/117871
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