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CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

Bower, M; Fisher, M; Hill, T; Reeves, I; Walsh, J; Orkin, C; Phillips, AN; ... UK CHIC Steering Comm, ; + view all (2009) CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK. HAEMATOL-HEMATOL J , 94 (6) 875 - 880. 10.3324/haematol.2008.002691. Gold open access

Abstract

Since the introduction of highly active antiretroviral therapy, there has been a decline in the incidence of non-Hodgkin's lymphoma among HIV-infected individuals. We described trends in the incidence of systemic non-Hodgkin's lymphoma in the UK CHIC Study from 19962006 and evaluated the association between immunosuppression and development of systemic non-Hodgkin's lymphoma: 286/23,155 (1.2%) individuals developed an AIDS-defining lymphoma (258 systemic). Younger age, receipt of highly active antiretroviral therapy and later calendar year were all independently associated with a reduced risk of systemic non-Hodgkin's lymphoma. A lower latest CD4 count was strongly associated with systemic non-Hodgkin's lymphoma, in patients who had (RR per log(2)(cells/mm(3)) higher: 0.62) and had not (0.70) received highly active antiretroviral therapy. Associations with other measures of immunosuppression, including nadir CD4 count, experience and duration of severe immunosuppression, were generally weaker. Earlier highly active antiretroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma.

Type: Article
Title: CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
Open access status: An open access publication
DOI: 10.3324/haematol.2008.002691
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC26885...
Keywords: non-Hodgkin's lymphoma, HIV, immunosuppression, CD4 count, cohort study, ACTIVE ANTIRETROVIRAL THERAPY, KAPOSIS-SARCOMA, INFECTED INDIVIDUALS, CANCER-RISK, AIDS, IMMUNODEFICIENCY, COHORT, ERA, PEOPLE, ADULTS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/117047
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