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A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus

Stephens, JW; Dhamrait, SS; Acharya, J; Humphries, SE; Hurel, SJ; (2006) A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus. J DIABETES COMPLICAT , 20 (5) 317 - 321. 10.1016/j.jdiacomp.2005.07.010.

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Abstract

Aims: The D allele of the ACE I/D gene variant is associated with higher tissue and serum ACE activity. Previously, studies have suggested an association between the D allele with the microvascular complications of diabetes. The aim of this study was to explore the impact of this genotype in relation to clinically manifest peripheral neuropathy (PN) in a cohort of subjects with type 2 diabetes mellitus (type 2 DM). Methods: Five hundred and seventy-two Caucasian subjects (230 females, 342 males) with type 2 DM were recruited from the diabetes clinic at University College London Hospitals NHS Trust. Clinically manifest PN was determined from a standardized clinical examination. Results: The ACE I/D genotype distribution was in Hardy-Weinberg equilibrium. In the whole group, no significant association was seen between genotype and PN; however, when stratified by sex, the D allele was associated with PN in females but not in males. The odds ratio (OR) for PN in the D allele carriers compared to those homozygous for the I allele was significantly higher in females [OR 2.93 (1.09-7.63), P=.027] but not in males [OR 1.2 (0.61-2.36), P=.60]. Conclusions: The presence of the D allele is associated with increased risk of peripheral neuropathy in females but not in male subjects with type 2 DM, suggesting a role for the renin-angiotensin system in the development of PN. (c) 2006 Elsevier Inc. All rights reserved.

Type:Article
Title:A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus
DOI:10.1016/j.jdiacomp.2005.07.010
Keywords:diabetes, neuropathy, ACE, gene variant, female, ANGIOTENSIN-CONVERTING-ENZYME, INSERTION/DELETION POLYMORPHISM, POSTMENOPAUSAL WOMEN, REPLACEMENT THERAPY, OXIDATIVE STRESS, RISK, MICROALBUMINURIA, COMPLICATIONS, PROGRESSION, GENOTYPE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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