EFFECT OF ZINC ON THE OSMOTIC FRAGILITY OF NORMAL AND SICKLE ERYTHROCYTES.
TRACE ELEM MED
1 - 5.
The zinc concentrations of erythrocytes from healthy volunteers and patients with sickle cell anemia were increased in vitro to 10 - 15 times normal by incubation with zinc and the chelator ethyl maltol. There was no immediate effect on osmotic fragility, but after incubation for 24 hours the osmotic fragilities of both normal and sickle cells were lower in the zinc-loaded samples (mean zinc concentration 0.40 moles Zn/mole hemoglobin) than the paired samples incubated without zinc (0.033 moles Zn/mole hemoglobin). The effect was not due to a change of mean cell volume but may be due to an interaction of zinc at the plasma membrane. Additional zinc may therefore reduce hemolysis of sickle erythrocytes in vivo.
|Title:||EFFECT OF ZINC ON THE OSMOTIC FRAGILITY OF NORMAL AND SICKLE ERYTHROCYTES|
|Keywords:||ERYTHROCYTE, OSMOTIC FRAGILITY, SICKLE-CELL ANEMIA, ZINC, CELL-ANEMIA SUBJECTS, RATS, HEMOGLOBIN, DEFICIENCY, DISEASE, MEMBRANES, BINDING|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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