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A novel method for the preparation of biodegradable microspheres for protein drug delivery

Pareta, R.; Edirisinghe, M.J.; (2006) A novel method for the preparation of biodegradable microspheres for protein drug delivery. Journal of The Royal Society Interface , 3 (9) pp. 573-582. 10.1098/rsif.2006.0120.

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Abstract

Microspheres are potential candidates for the protein drug delivery. In this work, we prepared polymer-coated starch/bovine serum albumin (BSA) microspheres using co-axial electrohydrodynamic atomization (CEHDA). First, starch solution in dimethyl sulphoxide (DMSO) was prepared and then an aqueous solution of BSA was added to it to make a starch–BSA solution. Subsequently, this solution was made to flow through the inner capillary, while the polymer, polydimethylsiloxane (PDMS), flowed through the outer capillary. On collection, filtration and subsequent drying, near-monodisperse microspheres of 5–6μm in size were obtained. The microspheres were characterized by Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy. Cumulative BSA release was investigated by UV spectroscopy. BSA structure and activity was preserved in the microspheres and its release in 0.01M phosphate buffered saline (PBS) was studied over a period of 8 days. There was an initial burst with 32wt% of total BSA released in 2h. Overall 75wt% of BSA was released over a 7 day period.

Type:Article
Title:A novel method for the preparation of biodegradable microspheres for protein drug delivery
DOI:10.1098/rsif.2006.0120
Publisher version:http://dx.doi.org/10.1098/rsif.2006.0120
Language:English
Keywords:Starch, co-axial electrohydrodynamic atomization, microspheres, protein release
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering

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