Sadowski, MI and Jones, DT (2009) The sequence-structure relationship and protein function prediction. CURR OPIN STRUC BIOL , 19 (3) 357 - 362. 10.1016/j.sbi.2009.03.008.
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An incomplete understanding of protein sequence/structure/function relationships causes man difficulties for prediction methods. The highly complex nature of these relationships is a consequence of the interplay between physics and evolution that has been studied using a wide array of experimental and theoretical techniques. We review recent findings relating to conservation of sequence, structure and function and discuss their use in developing improved prediction methods.
|Title:||The sequence-structure relationship and protein function prediction|
|Keywords:||GENE ONTOLOGY ANNOTATIONS, CONVERGENT EVOLUTION, PARACELSUS CHALLENGE, DOMAIN-STRUCTURES, LIGAND-BINDING, SITES, IDENTITY, DESIGN, FOLDS, CLASSIFICATION|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science > Computer Science|
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