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The sequence-structure relationship and protein function prediction

Sadowski, MI; Jones, DT; (2009) The sequence-structure relationship and protein function prediction. CURR OPIN STRUC BIOL , 19 (3) 357 - 362. 10.1016/j.sbi.2009.03.008.

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Abstract

An incomplete understanding of protein sequence/structure/function relationships causes man difficulties for prediction methods. The highly complex nature of these relationships is a consequence of the interplay between physics and evolution that has been studied using a wide array of experimental and theoretical techniques. We review recent findings relating to conservation of sequence, structure and function and discuss their use in developing improved prediction methods.

Type:Article
Title:The sequence-structure relationship and protein function prediction
DOI:10.1016/j.sbi.2009.03.008
Keywords:GENE ONTOLOGY ANNOTATIONS, CONVERGENT EVOLUTION, PARACELSUS CHALLENGE, DOMAIN-STRUCTURES, LIGAND-BINDING, SITES, IDENTITY, DESIGN, FOLDS, CLASSIFICATION
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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