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Early changes in water diffusion, perfusion, T-1, and T-2 during focal cerebral ischemia in the rat studied at 8.5 T

Calamante, F; Lythgoe, MF; Pell, GS; Thomas, DL; King, MD; Busza, AL; Sotak, CH; ... Gadian, DG; + view all (1999) Early changes in water diffusion, perfusion, T-1, and T-2 during focal cerebral ischemia in the rat studied at 8.5 T. MAGN RESON MED , 41 (3) 479 - 485.

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Abstract

The time evolution of water diffusion, perfusion, T-1, and T-2 is investigated at high magnetic field (8.5 T) following permanent middle cerebral artery occlusion in the rat. Cerebral blood flow maps were obtained using arterial spin tagging. although the quantitative perfusion measurements in ischemic tissue still pose difficulties, the combined perfusion and diffusion data nevertheless distinguish between a "moderately affected area," with reduced perfusion but normal diffusion; and a "severely affected area," in which both perfusion and diffusion are significantly reduced. Two novel magnetic resonance imaging observations are reported, namely, a decrease in T-2 and an increase in T-1, both within the first few minutes of ischemia. The rapid initial decrease in T-2 is believed to be associated with an increase in deoxyhemoglobin levels, while the initial increase in T-1 may be related to several factors, such as flow effects, an alteration in tissue oxygenation, and changes in water environment. Magn Reson Med 41:479-485, 1999. (C) 1999 Wiley-Liss, Inc.

Type: Article
Title: Early changes in water diffusion, perfusion, T-1, and T-2 during focal cerebral ischemia in the rat studied at 8.5 T
Keywords: stroke, arterial spin tagging, diffusion tensor trace, deoxyhemoglobin, TRANSFER CONTRAST MTC, BLOOD-FLOW, MAGNETIZATION-TRANSFER, RELAXATION-TIMES, ARTERY OCCLUSION, BRAIN, SPECTROSCOPY, STATE, COEFFICIENT, DEPENDENCE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/116370
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