UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Reperfusion in a gerbil model of forebrain ischemia using serial magnetic resonance FAIR perfusion imaging

Pell, GS; Lythgoe, MF; Thomas, DL; Calamante, F; King, MD; Gadian, DG; Ordidge, RJ; (1999) Reperfusion in a gerbil model of forebrain ischemia using serial magnetic resonance FAIR perfusion imaging. STROKE , 30 (6) 1263 - 1270.

Full text not available from this repository.

Abstract

Background and Purpose-Existing methods for the quantitative measurement of the changing cerebral blood flow (CBF) during reperfusion suffer from poor spatial or temporal resolution. The aim of this study was to implement a recently developed MRI technique for quantitative perfusion imaging in a gerbil model of reperfusion. Flow-sensitive alternating inversion recovery (FAIR) is a noninvasive procedure that uses blood water as an endogenous tracer.Methods-Bilateral forebrain ischemia of 4 minutes' duration was induced in gerbils (n=8). A modified version of FAIR with improved time efficiency was used to provide CBF maps with a time resolution of 2.8 minutes after recirculation had been initiated. Quantitative diffusion imaging was also performed at intervals during the reperfusion period.Results-On initiating recirculation after the transient period of ischemia, the FAIR measurements demonstrated either a symmetrical, bilateral pattern of flow impairment (n=4) or an immediate side-to-side difference that became apparent with respect to the cerebral hemispheres in the imaged slice (n=4), The flow in each hemisphere displayed a pattern of recovery close to the preocclusion level or, alternatively, returned to a lower level before displaying a delayed hypoperfusion and a subsequent slow recovery, The diffusion measurements during this latter response suggested the development of cell swelling during the reperfusion phase in the striatum,Conclusions-The CBF during the reperfusion period was monitored with a high time resolution, noninvasive method, This study demonstrates the utility of MRI techniques in following bloodflow changes and their pathophysiological consequences.

Type: Article
Title: Reperfusion in a gerbil model of forebrain ischemia using serial magnetic resonance FAIR perfusion imaging
Keywords: animal models, cerebral ischemia, transient, magnetic resonance imaging, perfusion, reperfusion, CEREBRAL BLOOD-FLOW, APPARENT DIFFUSION-COEFFICIENT, P-31 NMR-SPECTROSCOPY, HYDROGEN CLEARANCE, ENERGY-METABOLISM, CARDIAC-ARREST, RAT-BRAIN, RECOVERY, QUANTIFICATION, INJURY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/116369
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item