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Mechanism-based classifications of pain and analgesic drug discovery

Woolf, CJ; Borsook, D; Koltzenburg, M; (2003) Mechanism-based classifications of pain and analgesic drug discovery. In: Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery. (pp. 1-8).

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Abstract

© 2003 by Marcel Dekker, Inc. Two parallel processes characterize the contemporary pain field: first, enormous progress is being made in the discovery of the cellular and molecular mechanisms responsible for the pathogenesis of pain; second, there is a growing appreciation that multiple mechanisms contribute to common clinical pain syndromes. Both of these will have a considerable influence on novel analgesic development, the former in discovering novel molecular targets, and the latter in defining what therapeutic approaches are required for particular components of particular pain syndromes. The aim of this chapter is to show how a mechanism-based classification is likely to have profound implications; drugs may be developed that target distinct mechanisms, and clinicians may eventually be armed with more reliable and valid diagnostic tools for treatment and clinical investigation.

Type: Book chapter
Title: Mechanism-based classifications of pain and analgesic drug discovery
ISBN: 0824788656
ISBN-13: 9780824788650
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/116346
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