Corneveaux, JJ and Myers, AJ and Allen, AN and Pruzin, JJ and Ramirez, M and Engel, A and Nalls, MA and Chen, KW and Lee, W and Chewning, K and Villa, SE and Meechoovet, HB and Gerber, JD and Frost, D and Benson, HL and O'Reilly, S and Chibnik, LB and Shulman, JM and Singleton, AB and Craig, DW and Van Keuren-Jensen, KR and Dunckley, T and Bennett, DA and De Jager, PL and Heward, C and Hardy, J and Reiman, EM and Huentelman, MJ (2010) Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. HUM MOL GENET , 19 (16) 3295 - 3301. 10.1093/hmg/ddq221.
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Abstract
In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in unusually large data sets, and previously implicated CST3 and ACE SNPs. In the cases of CLU, PICALM and CR1, as well as in APOE, the odds ratios we find are slightly larger than those previously reported in clinical samples, consistent with what we believe to be more accurate classification of disease in the clinically characterized and neuropathologically confirmed AD cases and controls.
| Type: | Article |
|---|---|
| Title: | Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals |
| DOI: | 10.1093/hmg/ddq221 |
| Keywords: | APOLIPOPROTEIN-E GENOTYPES, WHOLE-GENOME ASSOCIATION, COMMUNITY POPULATION, IDENTIFIES VARIANTS, WIDE ASSOCIATION, OLDER PERSONS, TYPE-4 ALLELE, ONSET, RISK, GENE |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience |
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