UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The contribution of amphetamine metabolites of (-)-deprenyl to its antiparkinsonian properties.

Elsworth, JD; Sandler, M; Lees, AJ; Ward, C; Stern, GM; (1982) The contribution of amphetamine metabolites of (-)-deprenyl to its antiparkinsonian properties. J Neural Transm , 54 (1-2) pp. 105-110.

Full text not available from this repository.

Abstract

Although (-)-deprenyl is known to be metabolized to methamphetamine and amphetamine, two small-scale double-blind trials indicate that neither metabolite contributes to all therapeutic benefit conferred by this drug in certain patients with Parkinson's disease: the manipulation of urinary pH, which alters the rate of excretion of these metabolites, failed to change the response pattern; substitution of a metabolite mixture for active drug caused a falling off in benefit.

Type: Article
Title: The contribution of amphetamine metabolites of (-)-deprenyl to its antiparkinsonian properties.
Location: Austria
Keywords: Amphetamine, Double-Blind Method, Drug Therapy, Combination, Humans, Hydrogen-Ion Concentration, Levodopa, Methamphetamine, Middle Aged, Parkinson Disease, Phenethylamines, Selegiline
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/116118
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item