Hardy, J and Lees, AJ (2005) Parkinson's disease: A broken nosology. MOVEMENT DISORDERS , 20 S2 - S4. 10.1002/mds.20532.
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Abstract
Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the et-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia. (c) 2005 Movement Disorder Society.
| Type: | Article |
|---|---|
| Title: | Parkinson's disease: A broken nosology |
| Location: | Innsbruck, AUSTRIA |
| DOI: | 10.1002/mds.20532 |
| Keywords: | nosology, Parkinson's disease, Lewy body dementia, ALPHA-SYNUCLEIN, ALZHEIMERS-DISEASE, LEWY BODIES, DIAGNOSIS, DEMENTIA, GENETICS, MUTATION, BODY, FAMILIES |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > RLW Institute of Neurological Sciences |
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