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Dementia with Lewy bodies from the perspective of tauopathy

Iseki, E; Togo, T; Suzuki, K; Katsuse, O; Marui, W; de Silva, R; Lees, A; ... Kosaka, K; + view all (2003) Dementia with Lewy bodies from the perspective of tauopathy. ACTA NEUROPATHOL , 105 (3) 265 - 270. 10.1007/s00401-002-0644-3.

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Abstract

We immunohistochemically investigated the prevalence and pattern of phosphorylated tau accumulation in neurons and glia in 46 cases of dementia with Lewy bodies (DLB). Tau-positive neurons composed of neurofibrillary tangles (NFT) and pretangle neurons were found in the hippocampal area in all 46 cases, although the ratio of pretangle neurons in tau-positive neurons was higher in the cases showing low NFT stages. Tau-positive astrocytes were found in the periventricular area in 18 of 46 cases, and partly represented argyrophilic thorn-shaped astrocytes. In contrast, tau-positive oligodendroglia were found in the subcortical white matter in 9 of 46 cases, and represented argyrophilic coiled bodies. Tau-positive argyrophilic grains were found in the hippocampal area in the same cases as those with coiled bodies. The 9 cases with tau-positive coiled bodies and grains were included in the 18 cases with tau-positive astrocytes, and showed larger proportions in the low NFT stages than the 46 cases with tau-positive neurons. Tau-positive neurons were positive both to anti-three-repeat (3R) and -4R tau-specific antibodies, while tau-positive astrocytes, coiled bodies and grains were predominantly positive to anti-4R tau-specific antibody. These tau-positive structures were negative to anti-a-synuclein antibody. These findings suggest that the tau accumulation in DLB represents both tau-positive neurons with all six tau isoforms and tau-positive astrocytes, coiled bodies and grains with the 4R tau isoform, and that the different cytoskeletal abnormalities form a link between some neurodegenerative dementing disorders including DLB.

Type: Article
Title: Dementia with Lewy bodies from the perspective of tauopathy
DOI: 10.1007/s00401-002-0644-3
Keywords: dementia with Lewy bodies, tauopathy, neurofibrillary tangles, glial fibrillary tangles, argyrophilic grains, ARGYROPHILIC GRAIN DISEASE, PROGRESSIVE SUPRANUCLEAR PALSY, HYPERPHOSPHORYLATED TAU-PROTEIN, GLIAL FIBRILLARY TANGLES, CORTICOBASAL DEGENERATION, NEUROFIBRILLARY TANGLES, ALZHEIMERS-DISEASE, NEURODEGENERATIVE DISEASES, PARKINSONS-DISEASE, ALPHA-SYNUCLEIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/116019
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