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Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs

Perry, EK; Kilford, L; Lees, AJ; Burn, DJ; Perry, RH; (2003) Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs. ANN NEUROL , 54 (2) 235 - 238. 10.1002/ana.10639.

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Abstract

The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.

Type: Article
Title: Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs
DOI: 10.1002/ana.10639
Keywords: AMYLOID PRECURSOR PROTEIN, MUSCARINIC RECEPTOR ACTIVATION, CEREBROSPINAL-FLUID, TAU-PHOSPHORYLATION, BETA, BRAIN, AGONISTS, CELLS, REDUCTION, SECRETION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/116008
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