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The neuro-behavioural syndrome of brainstem disease

Omar, R; Warren, JD; Ron, MA; Lees, AJ; Rossor, MN; Kartsounis, LD; (2007) The neuro-behavioural syndrome of brainstem disease. NEUROCASE , 13 (5-6) 452 - 465. 10.1080/13554790802001403.

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Abstract

We describe two patients with isolated brainstem lesions who exhibited behavioural and cognitive changes that are commonly associated with frontal lobe pathology, as leading clinical features. These cases illustrate the role of distributed neural networks in cognitive and behavioural processes. The brainstem, frontal-subcortical and limbic systems are extensively and reciprocally linked via neurotransmitter projection pathways. We argue that cognitive and behavioural features in patients with brainstem lesions reflect remote effects of brainstem structures on frontal lobe and limbic regions, as a consequence of disruption to ascending neurotransmitter pathways.

Type: Article
Title: The neuro-behavioural syndrome of brainstem disease
DOI: 10.1080/13554790802001403
Keywords: frontal lobe, brainstem, cognitive, PEDUNCULOPONTINE TEGMENTAL NUCLEUS, RHESUS-MONKEY, COGNITIVE IMPAIRMENT, CHOLINERGIC NEURONS, PREFRONTAL CORTEX, FRONTAL SYNDROME, LESIONS, PROJECTIONS, DYSFUNCTION, DIASCHISIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/115973
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