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Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy

Warren, NM; Piggott, MA; Greally, E; Lake, M; Lees, AJ; Burn, DJ; (2007) Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy. MOVEMENT DISORD , 22 (11) 1594 - 1600. 10.1002/mds.21573.

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Abstract

Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative disorder. In contrast to Parkinson's disease (PD) and dementia with Lewy bodies (DLB), replacement therapy with dopaminergic and cholinergic agents in PSP has been disappointing. The neurochemical basis for this is unclear. Our objective was to measure dopaminergic and cholinergic receptors in the basal ganglia of PSP and control brains. We measured, autoradiographically, dopaminergic (dopamine transporter, 1 251 PE2I and dopamine D2 receptors, 1251 epidepride) and cholinergic (nicotinic alpha 402 receptors, 1251 51A85380 and muscarinic M I receptors, 3 H pirenzepine) parameters in the striatum and pallidum of pathologically confirmed PSP cases (n = 15) and controls (n = 32). In PSP, there was a marked loss of dopamine transporter and nicotinic alpha 4 beta 2 binding in the striatum and pallidum, consistent with loss of nigrostriatal neurotics. Striatal D2 receptors were increased in the caudate and muscarinic Ml receptors were unchanged compared with controls. These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/Ml receptors. (c) 2007 Movement Disorder Society.

Type: Article
Title: Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy
DOI: 10.1002/mds.21573
Keywords: dopaminergic, cholinergic, progressive supranuclear palsy, basal ganglia, RICHARDSON-OLSZEWSKI-SYNDROME, MULTIPLE SYSTEM ATROPHY, PARKINSONS-DISEASE, RECEPTOR-BINDING, GLOBUS-PALLIDUS, TRANSDERMAL NICOTINE, ALZHEIMERS-DISEASE, NATURAL-HISTORY, CLINICAL-FEATURES, MESSENGER-RNA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/115945
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