UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Antiparkinsonian activity of L-propyl-L-leucyl-glycinamide or melanocyte-inhibiting factor in MPTP-treated common marmosets

Katzenschlager, R; Jackson, MJ; Rose, S; Stockwell, K; Tayarani-Binazir, KA; Zubair, M; Smith, LA; ... Lees, AJ; + view all (2007) Antiparkinsonian activity of L-propyl-L-leucyl-glycinamide or melanocyte-inhibiting factor in MPTP-treated common marmosets. MOVEMENT DISORD , 22 (5) 715 - 719. 10.1002/mds.21256.

Full text not available from this repository.

Abstract

The neuropeptide melanocyte-inhibiting factor (MIF) or L-propyl-L-leucyl-glycinamide (PLG) has been reported in some studies to improve the motor signs of Parkinson's disease (PD) and in rodent models of PD. In this study of oral and intravenous MIF in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmosets, a wide range of doses of MIF administered alone (0.25, 1, 2, 5, 10, 20 mg/kg orally) did not increase locomotor activity, relieve motor disability, or induce dyskinesias. When MIF (1.0 and 5.0 mg/kg orally or 10 and 20 mg/kg intravenously) was administered concomitantly with levodopa/benserazide, no significant differences in motor function or dyskinesias were observed compared with levodopa/henserazide alone. The results of this first study of MIF in the marmoset MPTP model provide no encouragement for the reinvestigation of MIF in the clinical management of the motor signs of PD. (c) 2007 Movement Disorder Society.

Type: Article
Title: Antiparkinsonian activity of L-propyl-L-leucyl-glycinamide or melanocyte-inhibiting factor in MPTP-treated common marmosets
DOI: 10.1002/mds.21256
Keywords: Parkinson's disease, dyskinesia, marmoset, melanocyte-inhibiting factor (MIF), DOPAMINE-RECEPTOR AGONIST, PARKINSONS-DISEASE, MIF-I, STIMULATING HORMONE, PEPTIDOMIMETIC ANALOG, PRO-LEU-GLY-NH2 PLG, HYPOTHALAMIC FACTOR, PROLYL, AMIDE, POTENTIATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/115943
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item