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Acute effects of ketamine on memory systems and psychotic symptoms in healthy volunteers

Morgan, CJA; Mofeez, A; Brandner, B; Bromley, L; Curran, HV; (2004) Acute effects of ketamine on memory systems and psychotic symptoms in healthy volunteers. NEUROPSYCHOPHARMACOL , 29 (1) 208 - 218. 10.1038/sj.npp.1300342.

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Abstract

N-methyl-D-aspartate (NMDA) receptor antagonists have been demonstrated to induce schizophrenia-like symptoms and cognitive impairment in humans. The NMDA receptor has been strongly implicated in memory, but research to date on the effects of NMDA antagonists has examined only some aspects of human memory functions. This study used a double-blind, placebo-controlled, independent groups design with 54 healthy volunteers to examine the effects of infusions of two doses (0.4, 0.8 mg/kg) of the NMDA antagonist ketamine upon the five human memory systems, aspects of executive functioning and schizophrenia-like and dissociative symptoms. Ketamine produced a dose-dependent impairment to episodic and working memory and a slowing of semantic processing. Ketamine also impaired recognition memory and procedural learning. Attention, perceptual priming and executive functioning were not affected following the drug. In addition, ketamine induced schizophrenia-like and dissociative symptoms, which were not correlated with the cognitive measures. These data suggest that, in humans, ketamine produces a selective pattern of impairments to working, episodic, and procedural memory but not to perceptual priming, attention or aspects of executive functioning.

Type: Article
Title: Acute effects of ketamine on memory systems and psychotic symptoms in healthy volunteers
DOI: 10.1038/sj.npp.1300342
Keywords: memory, glutamate, schizophrenia, N-methyl-D-aspartate receptors, ketamine, cognition, WORKING-MEMORY, PREFRONTAL CORTEX, RECOGNITION MEMORY, CONSCIOUS AWARENESS, DISSOCIATION, ANTAGONIST, DOPAMINE, HUMANS, NEUROTRANSMISSION, SCHIZOPHRENIA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: http://discovery.ucl.ac.uk/id/eprint/11587
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