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Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease - a prospective study

Shoab, SS; Porter, J; Scurr, JH; Coleridge-Smith, PD; (1999) Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease - a prospective study. EUR J VASC ENDOVASC , 17 (4) 313 - 318.

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Abstract

Background: endothelial activation is important in the pathogenesis of skin changes due to chronic venous disease (CVD). Purified micronised flavonoid Junction has been used for symptomatic treatment of CVD for a considerable period of time. The exact mode of action of these compounds remains unknown.Aim: to study the effects of micronised purified flavonoidic fraction (Daflon(R) 500 mg, Servier, France) treatment on plasma markers of endothelial activation.Materials and methods: twenty patients with chronic venous disease were treated for 60 days with DAFLON(R) 500 mg twice daily. Duplex ultrasonography and PPG was used to assess the venous disease, Blood was collected from a foot vein immediately before starting treatment and within 1 week of stopping treatment. Plasma markers of endothelial activation were measured using commercial ELISA kits.Results: reduction in the level of ICAM-1, 32% (141 ng/ml: 73 ng/ml) and VCAM 29% (1292 ng/ml: 717 ng/ml) was seen. Reduction in plasma lactoferrin (36% decrease, 760 ng/ml: 560 ng/ml) and VW factor occurred in the C4 group only.Conclusions: micronised purified flavonoidic fraction treatment for 60 days seems to decrease the levels of some plasma markers of endothelial activation. This could ameliorate the dermatological effects of (CVD). This could also explain some of the pharmacological actions of these compounds. Our study demonstrates the feasibility of using soluble endothelial adhesion molecules as markers for treatment.

Type: Article
Title: Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease - a prospective study
Keywords: DAFLON 500 MG, DOUBLE-BLIND, LEG, INSUFFICIENCY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/115456
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