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The factor VII activating protease G511E (Marburg) variant and cardiovascular risk

Ireland, H; Miller, GJ; Webb, KE; Cooper, JA; Humphries, SE; (2004) The factor VII activating protease G511E (Marburg) variant and cardiovascular risk. THROMB HAEMOSTASIS , 92 (5) 986 - 992. 10.1160/TH04-05-0275.

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Abstract

A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a prothrombotic state. The current study has addressed risk for coronary heart disease in a prospective study of cardiovascular disorders (Northwick Park Heart Study II). An interactive effect upon risk was found between the 511E allele and elevated levels of cholesterol and triglyceride. Fibrinogen could substitute for triglyceride levels in this risk-interaction analysis. The findings support the proposal that the FSAP511E allele exacerbates atherosclerosis or its clinical sequelae.

Type:Article
Title:The factor VII activating protease G511E (Marburg) variant and cardiovascular risk
DOI:10.1160/TH04-05-0275
Keywords:coronary heart disease, factor VII activating protease, SERINE-PROTEASE, HUMAN PLASMA, PURIFICATION, FSAP
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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