Assessment of reactive hyperaemia using real time zonal echo-planar flow imaging.
J Cardiovasc Magn Reson
The measurement of limb blood flow at rest and during reactive hyperaemia has potential as a marker of vascular health and endothelial function because it is the stimulus that causes flow-mediated dilatation, commonly measured as brachial arterial reactivity. Because the flow increases are short lived, they represent a significant challenge for measurement by cardiovascular magnetic resonance. In this study we used a real time, single shot zonal echo-planar imaging method (ZEPI) to study reactive hyperaemia in the femoral artery of five healthy volunteers. Flow velocity was measured every 78 msec. Changes in peak forward flow velocity during systole (580 vs. 390 mm/sec, p < 0.01) and minimum flow velocity (160 vs. 100 mm/sec, p < 0.01) were shown. With progressing improvement in spatial resolution, this technique will allow the accurate noninvasive determination of total flow, flow profile, and peak velocities in real time.
|Title:||Assessment of reactive hyperaemia using real time zonal echo-planar flow imaging.|
|Open access status:||An open access publication|
|Keywords:||Adult, Blood Flow Velocity, Echo-Planar Imaging, Femoral Artery, Humans, Hyperemia, Image Processing, Computer-Assisted, Leg, Male, Middle Aged|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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