Romeo, C and Eaton, S and Quant, PA and Spitz, L and Pierro, A (1999) Neonatal oxidative liver metabolism: effects of hydrogen peroxide, a putative mediator of septic damage. J Pediatr Surg , 34 (7) 1107 - 1111.
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Abstract
Surgical neonates are at risk for sepsis and liver dysfunction. These complications are more common in preterm neonates and in those who receive total parenteral nutrition. Elevated levels of reactive oxygen species (eg, hydrogen peroxide) have been reported in these "at-risk" patients and may be the mediators of liver impairment via their effect on oxidative energy metabolism. The aim of this study was to test the hypothesis that elevated levels of hydrogen peroxide (H2O2) impair neonatal liver oxidative energy metabolism.
| Type: | Article |
|---|---|
| Title: | Neonatal oxidative liver metabolism: effects of hydrogen peroxide, a putative mediator of septic damage. |
| Location: | UNITED STATES |
| Language: | English |
| Keywords: | Adenosine Triphosphate, Animals, Animals, Newborn, Cattle, Cells, Cultured, Dose-Response Relationship, Drug, Drug Interactions, Female, Hydrogen Peroxide, Liver, Methacrylates, Oligomycins, Oxidants, Oxidative Stress, Oxygen Consumption, Probability, Rats, Rats, Wistar, Reference Values, Thiazoles |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Nutritional and Surgical Science > ICH - Surgery Unit |
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