Fitzmaurice, RJ and Ahern, JM and Caddick, S (2009) Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates. ORG BIOMOL CHEM , 7 (2) 235 - 237. 10.1039/b819235a.
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Abstract
A new and simple protocol for the direct functionalisation of aldehydes with concomitant conversion into ketones via C-C bond formation has been developed. The reaction effectively enables the direct C-H activation of an aldehyde by mixing of an aldehyde and a vinyl sulfonate under aerobic conditions or using hydrogen peroxide as a sub-stoichiometric reagent.
| Type: | Article |
|---|---|
| Title: | Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates |
| DOI: | 10.1039/b819235a |
| Keywords: | POLARITY-REVERSAL CATALYST, N-HYDROXYPHTHALIMIDE NHPI, RADICAL-CHAIN ADDITION, INTERMOLECULAR HYDROACYLATION, ACYL RADICALS, ALKENES, SULFONAMIDES, ESTERS, DERIVATIVES, AMINOLYSIS |
| UCL classification: | UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry UCL > VP Enterprise |
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