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Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates

Fitzmaurice, RJ; Ahern, JM; Caddick, S; (2009) Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates. ORG BIOMOL CHEM , 7 (2) 235 - 237. 10.1039/b819235a.

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Abstract

A new and simple protocol for the direct functionalisation of aldehydes with concomitant conversion into ketones via C-C bond formation has been developed. The reaction effectively enables the direct C-H activation of an aldehyde by mixing of an aldehyde and a vinyl sulfonate under aerobic conditions or using hydrogen peroxide as a sub-stoichiometric reagent.

Type:Article
Title:Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates
DOI:10.1039/b819235a
Keywords:POLARITY-REVERSAL CATALYST, N-HYDROXYPHTHALIMIDE NHPI, RADICAL-CHAIN ADDITION, INTERMOLECULAR HYDROACYLATION, ACYL RADICALS, ALKENES, SULFONAMIDES, ESTERS, DERIVATIVES, AMINOLYSIS
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
UCL > VP Enterprise

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