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Scalable Reactor Design for Pharmaceuticals and Fine Chemicals Production. 3. A Novel Gas-Liquid Reactor for Catalytic Asymmetric Transfer Hydrogenation with Simultaneous Acetone Stripping

Sun, XY; Gavriilidis, A; (2008) Scalable Reactor Design for Pharmaceuticals and Fine Chemicals Production. 3. A Novel Gas-Liquid Reactor for Catalytic Asymmetric Transfer Hydrogenation with Simultaneous Acetone Stripping. ORG PROCESS RES DEV , 12 (6) 1218 - 1222. 10.1021/op800195k.

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Abstract

For the asymmetric transfer hydrogenation of acetophenone to its chiral alcohols, in the presence of homogeneous catalyst (1R,2S-amino-indanol/pentamethylcyclopentadienylrhodium), with isopropanol as hydrogen donor, prior investigation revealed that removal of the byproduct acetone from the reaction system shortens the required reaction time to achieve high conversion and reduces enantiomeric excess erosion. Since acetone removal efficiency is different in different batch reactor scales, this issue poses a scalability problem. Regardless of scale, the stirred vessel operated as a gas/liquid batch reactor has limitations with regards to allowable gas flow rate through the vessel due to impeller flooding. Therefore, reactor systems where high gas/liquid flow rate ratio can be employed are advantageous. In this work, a continuous reactor that utilises a micromesh structure to stabilise the gas/liquid interface is presented. The reactor can operate with high gas/liquid flow rate, resulting in efficient acetone removal, low reaction time, and high enantiomeric excess.

Type: Article
Title: Scalable Reactor Design for Pharmaceuticals and Fine Chemicals Production. 3. A Novel Gas-Liquid Reactor for Catalytic Asymmetric Transfer Hydrogenation with Simultaneous Acetone Stripping
DOI: 10.1021/op800195k
Keywords: SCALE-UP OBSTACLES, MEMBRANE CONTACTORS, SEPARATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/114258
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