UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Optimal delivery of chemotherapeutic agents in cancer

Dua, P; Dua, V; Pistikopoulos, EN; (2008) Optimal delivery of chemotherapeutic agents in cancer. COMPUTERS & CHEMICAL ENGINEERING , 32 (1-2) 99 - 107. 10.1016/j.compchemeng.2007.07.001.

Full text not available from this repository.

Abstract

Cancer refers to a set of diseases where normal cells of the body lose mechanisms which are responsible for controlling their growth and motility. Chemotherapy aims to kill these abnormal or cancer cells, however normal cells and healthy tissues are also adversely affected. Systematic modelling and optimization approaches can be employed to obtain effective chemotherapeutic protocol that minimizes the tumour cell population while limiting the damage to the normal cells. In this paper, two models for cancer chemotherapy are considered and the effect of the time of drug administration on the final tumour size is analyzed. The first model is cell cycle non-specific and considers all the cancer cells as belonging to one compartment whereas the second model is cell cycle specific and takes into account the effect of the drugs that act on cells at certain specific stages of the cell cycle. An optimal control problem is also formulated and solved for both the models so as to obtain the chemotherapeutic schedule which minimizes the final tumour size while taking into account the constraints on drug resistance and toxicity. For the first model a mixed integer dynamic optimization problem and for the second model a dynamic optimization problem are solved. The optimal chemotherapeutic drug administration profiles and the variation of number of cells with time are obtained and analyzed in detail. (C) 2007 Elsevier Ltd. All rights reserved.

Type: Article
Title: Optimal delivery of chemotherapeutic agents in cancer
Location: Garmisch Partenkirchen, GERMANY
DOI: 10.1016/j.compchemeng.2007.07.001
Additional information: Invalid ISBN han read from Web of Science.
Keywords: drug delivery systems, cancer, chemotherapy, optimal control, mixed integer dynamic optimization
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/114028
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item