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Colorimetric phage-based assay for detection of rifampin-resistant Mycobacterium tuberculosis

McNerney, R; Mallard, K; Urassa, HMR; Lemma, E; Donoghue, HD; (2007) Colorimetric phage-based assay for detection of rifampin-resistant Mycobacterium tuberculosis. Journal of Clinical Microbiology , 45 (4) 1330 - 1332. 10.1128/JCM.02028-06. Green open access

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Abstract

Tests based on bacteriophage replication enable rapid screening of Mycobacterium tuberculosis for drug resistance. We describe a novel broth-based colorimetric method for detecting phage replication. When clinical isolates were tested by this novel method, high concordance was observed with both the traditional phage assay and gene mutation analysis for detection of resistance to rifampin.

Type: Article
Title: Colorimetric phage-based assay for detection of rifampin-resistant Mycobacterium tuberculosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1128/JCM.02028-06
Publisher version: http://dx.doi.org/10.1128/JCM.02028-06
Language: English
Additional information: Originally published by ASM: http://dx.doi.org/10.1128/JCM.02028-06
Keywords: Susceptibility
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/113970
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