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Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway

Chanalaris, A; Lawrence, KM; Townsend, PA; Davidson, S; Jashmidi, Y; Stephanou, A; Knight, RD; ... Latchman, DS; + view all (2005) Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. BIOCHEM BIOPH RES CO , 328 (2) 442 - 448. 10.1016/j.bbrc.2005.01.001.

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Abstract

The UCN homologues SCP and SRP bind specifically to the CR FR2 receptor, whereas UCN binds to both CRFR1 and CRFR2. We have previously demonstrated that all three peptides are cardioprotective, and both the Akt and MAPK p42/44 pathways are essential for this effect. Here we tested the hypertrophic effects of these peptides. We examined the effects of the peptides on cell area, protein synthesis, and induction of the natriuretic peptides ANP and BNP. All three peptides were able to increase all the markers of hypertrophy examined, with SCP being the most potent of the three, followed by UCN and SRP last. In addition, we provide a mechanism of action for the three peptides and show that Akt phosphorylation is important for their hypertrophic action, whereas MAPK p42/44 is not involved in this effect. (C) 2005 Published by Elsevier Inc.

Type: Article
Title: Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway
DOI: 10.1016/j.bbrc.2005.01.001
Keywords: urocortin, stresscopin, stresscopin related peptide, hypertrophy, Akt, MAPK, natriuretic peptides, cardiomyocytes, CORTICOTROPIN-RELEASING-FACTOR, ATRIAL-NATRIURETIC-PEPTIDE, PROTEIN-KINASE-C, FACTOR CRF FAMILY, REPERFUSION INJURY, CARDIAC MYOCYTES, RAT CARDIOMYOCYTES, CELL-DEATH, HEART, RECEPTORS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH - Directors Office
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Genetics and Genomic Medicine Prog
URI: http://discovery.ucl.ac.uk/id/eprint/113539
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