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Sperm deliver a new second messenger: NAADP

Churchill, GC; O'Neill, JS; Masgrau, R; Patel, S; Thomas, JM; Genazzani, AA; Galione, A; (2003) Sperm deliver a new second messenger: NAADP. CURR BIOL , 13 (2) 125 - 128.

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Abstract

NAADP is a highly potent mobilizer of Ca2+ [1, 2], which in turn triggers Ca2+-induced Ca2+ release pathways [3-6] in a wide range of species [2, 7]. Nevertheless, NAADP is not presently classified as a second messenger because it has not been shown to increase in response to a physiological stimulus. We now report a dramatic increase in NAADP during sea urchin egg fertilization that was largely due to production in sperm upon contacting egg jelly. The NAADP bolus plays a physiological role upon delivery to the egg based on its ability to induce a cortical flash, a depolarization-induced activation of L-type Ca2+ channels. Moreover, the sperm-induced cortical flash was eliminated in eggs desensitized to NAADP. We conclude that an NAADP increase plays a physiologically relevant role during fertilization and provides the first conclusive demonstration that NAADP is a genuine second messenger.

Type: Article
Title: Sperm deliver a new second messenger: NAADP
Keywords: ADENINE-DINUCLEOTIDE PHOSPHATE, SEA-URCHIN EGGS, INDUCED CA2+ RELEASE, CYCLIC ADP-RIBOSE, CA2+-MOBILIZING MESSENGER, INACTIVATION, BINDING, FERTILIZATION, COORDINATION, METABOLISM
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/113477
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