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Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma.

Behboudi, S; Pereira, SP; (2010) Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma. World J Hepatol , 2 (7) 256 - 260. 10.4254/wjh.v2.i7.256. Gold open access

Abstract

The presence of CD8 T cell responses to tumor associated antigens have been reported in patients with different malignancies. However, there is very little information on a comparable CD8 and CD4 T cell response to a tumor antigen in liver cancer patients. Here, we re-examine the kinetic and the pattern of T helper 1 and cytotoxic T lymphocyte responses to alpha-fetoprotein (AFP), a tumor rejection antigen in hepatocellular carcinoma (HCC). Then, we discuss the possibility of using AFP-based immunotherapy in combination with necrotizing treatments in HCC patients.

Type:Article
Title:Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma.
Location:China
Open access status:An open access publication
DOI:10.4254/wjh.v2.i7.256
Language:English
Additional information:PMCID: PMC2999293
Keywords:Alpha-fetoprotein, Cell-mediated immunity, Hepatocellular carcinoma, Immunotherapy

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