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Statin therapy and the acute inflammatory response after coronary artery bypass grafting

Brull, DJ; Sanders, J; Rumley, A; Lowe, GDO; Humphries, SE; Montgomery, HE; (2001) Statin therapy and the acute inflammatory response after coronary artery bypass grafting. AM J CARDIOL , 88 (4) 431 - +.

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Abstract

Preoperative statin therapy has been shown to improve cardiovascular outcome after coronary artery bypass grafting; however, the clinical gain achieved is in excess of the reduction in lipids. We demonstrate that statin therapy exerts a direct anti-inflammatory effect mediated through reduced interleukin-6 production.

Type:Article
Title:Statin therapy and the acute inflammatory response after coronary artery bypass grafting
Keywords:HEART-DISEASE, PRAVASTATIN, SURVIVAL, ATHEROSCLEROSIS, INTERLEUKIN-6, SIMVASTATIN, PROGRESSION, REDUCTION, WALL, MEN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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