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Role of the cerebellum in externally paced rhythmic finger movements

Del Olmo, MF; Cheeran, B; Koch, G; Rothwell, JC; (2007) Role of the cerebellum in externally paced rhythmic finger movements. J NEUROPHYSIOL , 98 (1) 145 - 152. 10.1152/jn.01088.2006.

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Abstract

Several studies have suggested that the cerebellum has an important role in timing of subsecond intervals. Previous studies using transcranial magnetic stimulation (TMS) to test this hypothesis directly have produced inconsistent results. Here we used 1-Hz repetitive TMS ( rTMS) for 10 min over the right or left cerebellar hemisphere to interfere transiently with cerebellar processing to assess its effect on the performance of a finger-tapping task. Subjects tapped with their right index finger for 1 min ( synchronization phase) with an auditory or visual cue at 0.5, 1, or 2 Hz; they continued for a further 1 min at the same rate with no cues ( continuation phase). The blocks of trials were performed in a random order. rTMS of the cerebellum ipsilateral to the movement increased the variability of the intertap interval but only for movements at 2 Hz that were made while subjects were synchronizing with an auditory cue. There was no effect on the continuation phase of the task when the cues were no longer present or on synchronization with a visual cue. Similar results were seen after stimulation over the contralateral dorsal premotor cortex but not after rTMS over supplementary motor area. There was no effect after rTMS over the ipsilateral right cervical nerve roots or over the ipsilateral primary motor cortex. The results support the hypothesis of neural network for event-related timing in the subsecond range that involves a cerebellar-premotor network.

Type: Article
Title: Role of the cerebellum in externally paced rhythmic finger movements
DOI: 10.1152/jn.01088.2006
Keywords: TRANSCRANIAL MAGNETIC STIMULATION, HUMAN MOTOR CORTEX, DORSOLATERAL PREFRONTAL CORTEX, LOW-FREQUENCY RTMS, BRAIN ACTIVATION, HUMANS, AREA, COORDINATION, REPRODUCTION, EXCITABILITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/112786
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