Huth, C and Heid, IM and Vollmert, C and Gieger, C and Grallert, H and Wolford, JK and Langer, B and Thorand, B and Klopp, N and Hamid, YH and Pedersen, O and Hansen, T and Lyssenko, V and Groop, L and Meisinger, C and Doring, A and Lowel, H and Lieb, W and Hengstenberg, C and Rathmann, W and Martin, S and Stephens, JW and Ireland, H and Mather, H and Miller, GJ and Stringham, HM and Boehnke, M and Tuomilehto, J and Boeing, H and Mohlig, M and Spranger, J and Pfeiffer, A and Wernstedt, I and Niklason, A and Lopez-Bermejo, A and Fernandez-Real, JM and Hanson, RL and Gallart, L and Vendrell, J and Tsiavou, A and Hatziagelaki, E and Humphries, SE and Wichmann, HE and Herder, C and Illig, T (2006) IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. DIABETES , 55 (10) 2915 - 2921. 10.2337/db06-0600.
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Abstract
Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G > C (rs1800795) and -573G > C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on > 20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G > C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G > C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
| Type: | Article |
|---|---|
| Title: | IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies |
| DOI: | 10.2337/db06-0600 |
| Keywords: | BODY-MASS INDEX, INTERLEUKIN-6 GENE, TNF-ALPHA, -174 G/C, METAANALYSIS, MELLITUS, IL-6, ASSOCIATION, C-174G, PLASMA |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
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