Huth, C; Heid, IM; Vollmert, C; Gieger, C; Grallert, H; Wolford, JK; ... Illig, T; + view all Huth, C; Heid, IM; Vollmert, C; Gieger, C; Grallert, H; Wolford, JK; Langer, B; Thorand, B; Klopp, N; Hamid, YH; Pedersen, O; Hansen, T; Lyssenko, V; Groop, L; Meisinger, C; Doring, A; Lowel, H; Lieb, W; Hengstenberg, C; Rathmann, W; Martin, S; Stephens, JW; Ireland, H; Mather, H; Miller, GJ; Stringham, HM; Boehnke, M; Tuomilehto, J; Boeing, H; Mohlig, M; Spranger, J; Pfeiffer, A; Wernstedt, I; Niklason, A; Lopez-Bermejo, A; Fernandez-Real, JM; Hanson, RL; Gallart, L; Vendrell, J; Tsiavou, A; Hatziagelaki, E; Humphries, SE; Wichmann, HE; Herder, C; Illig, T; - view fewer (2006) IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. DIABETES , 55 (10) 2915 - 2921. 10.2337/db06-0600.
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Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G > C (rs1800795) and -573G > C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on > 20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G > C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G > C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
|Title:||IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies|
|Keywords:||BODY-MASS INDEX, INTERLEUKIN-6 GENE, TNF-ALPHA, -174 G/C, METAANALYSIS, MELLITUS, IL-6, ASSOCIATION, C-174G, PLASMA|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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