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IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies

Huth, C; Heid, IM; Vollmert, C; Gieger, C; Grallert, H; Wolford, JK; ... Illig, T; + view all (2006) IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies. DIABETES , 55 (10) 2915 - 2921. 10.2337/db06-0600.

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Abstract

Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G > C (rs1800795) and -573G > C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on > 20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G > C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G > C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.

Type:Article
Title:IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
DOI:10.2337/db06-0600
Keywords:BODY-MASS INDEX, INTERLEUKIN-6 GENE, TNF-ALPHA, -174 G/C, METAANALYSIS, MELLITUS, IL-6, ASSOCIATION, C-174G, PLASMA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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