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1H NMR study of cerebral development in the rat.

Bates, TE; Williams, SR; Gadian, DG; Bell, JD; Small, RK; Iles, RA; (1989) 1H NMR study of cerebral development in the rat. NMR Biomed , 2 (5-6) pp. 225-229.

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Abstract

1H NMR spectroscopy of brain extracts was used to investigate the metabolic changes that take place during development of the neonatal rat brain. Data were obtained over the range 1-21 days. The concentration of N-acetylaspartate rose by a factor of 9 during this period, the most rapid rise occurring after day 9. The total creatine concentration rose from days 1-21, with a large increase between days 1 and 5. Taurine concentration rose until day 5, then fell from days 5-21. The concentration of choline-containing compounds fell during the 21 day period. The results are discussed in relation to brain development and conventional biochemical data. A major conclusion in relation to spectroscopy of children is that interpretation of changes seen in disease will require adequate data from age-matched controls.

Type: Article
Title: 1H NMR study of cerebral development in the rat.
Location: England
Keywords: Animals, Brain, Humans, Magnetic Resonance Spectroscopy, Male, Rats, Rats, Inbred Strains
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
URI: http://discovery.ucl.ac.uk/id/eprint/112253
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