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Antiretroviral Drug Resistance in HIV-1-Infected Patients with Low-Level Viremia

Mackie, NE; Phillips, AN; Kaye, S; Booth, C; Geretti, AM; UK Resistance Database, ; UK Collaborative HIV Cohort Study, ; (2010) Antiretroviral Drug Resistance in HIV-1-Infected Patients with Low-Level Viremia. J INFECT DIS , 201 (9) 1303 - 1307. 10.1086/651618.

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Abstract

This study characterized the prevalence and patterns of antiretroviral-drug-resistance mutations according to plasma human immunodeficiency virus type 1 (HIV-1) RNA load in a large population of patients with HIV-1 infection who underwent testing for resistance mutations in routine clinical practice. HIV-1 genotypic resistance test results with linked clinical data were obtained from national resistance and clinical databases in the United Kingdom. Among 7861 tests, detection of >= 1 resistance mutation was most frequent at viral loads of 300-10,000 copies/mL and decreased statistically significantly at viral loads of 110,000 copies/mL. Major resistance mutations were commonly detected in the subset of tests that were performed among patients with viral loads of ! 1000 copies/mL (1001 [12.7%] of 7861 tests). We conclude that HIV-1 genotypic resistance testing is informative for patients with low viral loads.

Type: Article
Title: Antiretroviral Drug Resistance in HIV-1-Infected Patients with Low-Level Viremia
DOI: 10.1086/651618
Keywords: DETECTABLE VIREMIA, INDIVIDUALS, UK
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/112208
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