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Specialization of the Rostral Prefrontal Cortex for Distinct Analogy Processes

Volle, E; Gilbert, SJ; Benoit, RG; Burgess, PW; (2010) Specialization of the Rostral Prefrontal Cortex for Distinct Analogy Processes. CEREB CORTEX , 20 (11) 2647 - 2659. 10.1093/cercor/bhq012. Gold open access

Abstract

Analogical reasoning is central to learning and abstract thinking. It involves using a more familiar situation (source) to make inferences about a less familiar situation (target). According to the predominant cognitive models, analogical reasoning includes 1) generation of structured mental representations and 2) mapping based on structural similarities between them. This study used functional magnetic resonance imaging to specify the role of rostral prefrontal cortex (PFC) in these distinct processes. An experimental paradigm was designed that enabled differentiation between these processes, by temporal separation of the presentation of the source and the target. Within rostral PFC, a lateral subregion was activated by analogy task both during study of the source (before the source could be compared with a target) and when the target appeared. This may suggest that this subregion supports fundamental analogy processes such as generating structured representations of stimuli but is not specific to one particular processing stage. By contrast, a dorsomedial subregion of rostral PFC showed an interaction between task (analogy vs. control) and period (more activated when the target appeared). We propose that this region is involved in comparison or mapping processes. These results add to the growing evidence for functional differentiation between rostral PFC subregions.

Type:Article
Title:Specialization of the Rostral Prefrontal Cortex for Distinct Analogy Processes
Open access status:An open access publication
DOI:10.1093/cercor/bhq012
Publisher version:http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2951846/?tool=pubmed
Keywords:analogy, BA 10, fMRI, reasoning, rostral prefrontal, STIMULUS-INDEPENDENT THOUGHT, POSITRON-EMISSION-TOMOGRAPHY, FRONTOPOLAR CORTEX, NEURAL BASIS, DEFAULT NETWORK, HUMAN COGNITION, WORKING-MEMORY, FUNCTIONAL CONNECTIVITY, WANDERING MINDS, FRONTAL-CORTEX
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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