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The stem cell movement

Smart, N; Riley, PR; (2008) The stem cell movement. CIRC RES , 102 (10) 1155 - 1168. 10.1161/CIRCRESAHA.108.175158.

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Abstract

Stem or progenitor cell-based strategies to combat ischemic heart disease and myocardial infarction, whether autologous transplantation or stimulation of resident populations, not only require detailed insight into transdifferentiation potential and functional coupling, but the efficacy of this approach is underpinned by the need to induce appropriate migration and homing to the site of injury. This review focuses on existing insights into the trafficking of stem cells in the context of cardiac regenerative therapy, with particular focus on the wide variety of potential sources of cells, critical factors that may regulate their migration, and how extrapolating from embryonic stem/progenitor cell behavior during cardiogenesis may reveal pathways implicit in the adult heart postinjury.

Type: Article
Title: The stem cell movement
DOI: 10.1161/CIRCRESAHA.108.175158
Keywords: cardiac stem cells, migration, homing, mobilization, ENDOTHELIAL PROGENITOR CELLS, COLONY-STIMULATING FACTOR, REGENERATE INFARCTED MYOCARDIUM, ZEBRAFISH HEART REGENERATION, EPICARDIUM-DERIVED CELLS, CORONARY-ARTERY-DISEASE, BONE-MARROW, HEMATOPOIETIC STEM, CARDIAC REPAIR, CHEMOKINE SDF-1
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/111878
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